The homepage of Balazs Hegedus

Main page Lab Homepage Curriculum vitae Publications Projects: Neurofibromin Glioma Invasion Glioma Motility (Movies) Laminin and motility Phd Dissertation Personal: SPETSES 2000 ERDÉLY 2001

Research papers: Hegedus B, Yeh TH, Lee DY, Emnett RJ, Li J, Gutmann DH: Neurofibromin regulates somatic growth through the hypothalamic-pituitary axis. Human Mol Genet 2008 Jul 9; Epub ahead of print. Elghazi L, Weiss AJ, Gould AP, Hegedus B, Gutmann DH, Bernal-Mizrachi E: Generation of a reporter mouse line expressing Akt and EGFP upon Cre-mediated recombination. Genesis 2008 May;46(5):256-64. Hegedus B, Banerjee D, Yeh T, Rothermich S, Perry A, Rubin JB, Garbow JR, Gutmann DH: Preclinical cancer therapy in a mouse model of Neurofibromatosis-1 optic glioma. Cancer Res 2008 Mar 1;68(5):1520-8. Hegedus B, Dasgupta B, Shin JE, Emnett RJ, Hart-Mahon EK, Elghazi L, Bernal-Mizrachi E, Gutmann DH: Neurofibromatosis-1 regulates neuronal and glial cell differentiation from neuroglial progenitors in vivo by both cAMP- and Ras-dependent mechanisms. Cell Stem Cell 2007 Oct 11;1: 443-457 Sandsmark DK, Zhang H, Hegedus B, Pelletier CL, Weber JD, Gutmann DH: Nucleophosmin mediates mammalian target of rapamycin-dependent actin cytoskeleton dynamics and proliferation in neurofibromin-deficient astrocytes. Cancer Res 2007 May 15;67: 4790-4799 Banerjee D, Hegedus B, Gutmann DH, Garbow JR: Detection and measurement of neurofibromatosis-1 mouse optic glioma in vivo. Neuroimage 2007 May 1;35(4):1434-7. Hegedus B, Marga F, Jakab K, Sharpe-Timms KL, Forgacs G: The interplay of cell-cell and cell-matrix interactions in the invasive properties of brain tumors. Biophys J 2006 Oct 1;91(7):2708-16 Dasgupta B, Yi Y, Hegedus B, Weber JD, Gutmann DH: Cerebrospinal fluid proteomic analysis reveals dysregulation of methionine aminopeptidase-2 expression in human and mouse neurofibromatosis 1-associated glioma Cancer Res 2005 Nov 1;65(21):9843-50 Sun M, Graham JS, Hegedus B, Marga F, Zhang Y, Forgacs G, Grandbois M: Multiple membrane tethers probed by atomic force microscopy Biophys J 2005 Dec;89(6):4320-9 Fazekas I, Hegedüs B, Bacsy E, Kerekes E, Slowik F, Balint K, Pasztor E: Characterization of human pituitary adenomas in cell cultures by light and electron microscopic morphology and immunolabeling Folia Histochem Cytobiol 2005;43(2):81-90 Mehes E, Czirok A, Hegedus B, Szabo B, Vicsek T, Satz J, Campbell K, Jancsik V: Dystroglycan is involved in laminin-1-stimulated motility of Muller glial cells: combined velocity and directionality analysis. Glia 2005 Mar;49(4):492-500 Hegedüs B, Zách J, Czirók A, Lövey J, Vicsek T: Irradiation and taxol treatment result in non-monotonous, dose-dependent changes in the motility of glioblastoma cells J Neurooncol 2004 Mar;67(1-2):147-157 Mehes E, Czirok A, Hegedus B, Vicsek T, Jancsik V: Laminin-1 increases motility, path-searching, and process dynamism of rat and mouse Muller glial cells in vitro: Implication of relationship between cell behavior and formation of retinal morphology Cell Motil Cytoskeleton 2002 Nov;53(3):203-13 Twal WO, Czirok A, Hegedus B, Knaak C, Chintalapudi MR, Okagawa H, Sugi Y, Argraves WS: Fibulin-1 suppression of fibronectin-regulated cell adhesion and motility J Cell Sci 2001 Dec;114(Pt 24):4587-98. Banfi B, Molnar G, Maturana A, Steger K, Hegedus B, Demaurex N, Krause KH: A Ca2+-activated NADPH oxidase in testis, spleen, and lymph nodes J Biol Chem 2001 Oct 5;276(40):37594-37601 Hegedüs B, Czirók A, Fazekas I, Bábel T, Madarász E and Vicsek T: Locomotion and proliferation of glioblastoma cells in vitro: statistical evaluation of videomicroscopic observations J Neurosurgery 2000 Mar;92(3):428-434 Reviews: Read TA, Hegedus B, Wechsler-Reya R, Gutmann DH: The neurobiology of neurooncology. Ann Neurol 2006 Jul;60(1):3-11 Selected abstracts:  Hungarian Neuropathological Society Spring Meeting, Budapest, 2004  3rd  Annual Meeting of Romanian Biophysical Society, 2003  3rd  Joint Meeting of the Hungarian-German Neuropathologists, Budapest, 2001 Budapest, March 27 2008.