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Main page Lab Homepage Curriculum vitae Publications Projects: Neurofibromin Glioma Invasion Glioma Motility (Movies) Laminin and motility Phd Dissertation Personal: SPETSES 2000 ERDÉLY 2001
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Neurofibromatosis-1 Neurofibromatosis-1 is a common inherited disorder and a cancer predispostion syndrome. About 15% of the patients develop optic pathway gliomas. To identify the molecular mechanisms underlying tumor development we study genetically engineered mice that develop tumors resembling the human pathology. We identified MetAP2 and nucleophosmin as important downstream targets of neurofibromin regulation of tumor cell proliferation. Dasgupta et al, 2005; Sandsmark et al, 2007 Furthermore we demonstrated that these genetically engineered mice provide a preclinical platform for antitumor research and treatment development. Hegedus et al, 2008 Other hallmarks of neurofibromatosis-1 are learning deficits and memory problems suggesting a role for neurofibromin in regulating neuronal function. In order to investigate the role of Nf1 in the early development of the central nervous system we also induced the loss of neurofibromin in the neural stem cells of the developing mouse embryo. Interestingly, the differentiation of glial and neuronal cell lineage was influenced by Ras and cAMP dependent manner, respectively. Hegedus et al, 2007 |